In 2010, we had the opportunity to assess the tortoise population in the Seri territory of western Sonora, Mexico, and we visited several sites on the mainland and two sites on Isla Tiburón with our local Seri host, Ernesto Molina. This area consists of a magnificent representation of Sonoran desert scrub that includes a beautiful mosaic of saguaro, organ pipe, senita, and cardón columnar cactus. Part of the impetus of surveying here was to revisit several areas where tortoise surveys were conducted in 2001 and 2002 in response to reports by the Seri Indians of high Desert Tortoise mortality. At that time, the survey team led by Mercy Vaughn, Felipe Rodriguez Garcia, Gary Nabhan, and Patricia West found very high rates of recent mortality at all sites that raised concerns about the status of the Mexican populations of the species. The effort in 2010 was an opportunity to revisit these sites, and, unlike the first survey effort, we had permits to collect blood samples for further disease testing. Although we did find tortoise carcasses, the good news was we did not observe nearly so many as were found in 2001 to 2002 or other signs of recent mortality. In addition, we found very limited incidence of upper respiratory tract disease that occurs, sometimes commonly, in populations in the United States.